Senior Manager, Marketing & Commercial Excellence

About

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.

Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR‑β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Our success is driven by our people. We are building a dynamic, inclusive, and high‑performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.

Core Responsibilities

• Responsible for day‑to‑day promotional review committee (PRC) operations such as scheduling and facilitating PRC meetings and effectiveness, reinforcing PRC processes, managing Veeva workflows (submissions, QC, approvals, expirations, reporting), performing quality control checks, conducting PRC onboarding/training, etc.
• Support regulatory operations on promotional material submissions to FDA/OPDP (2253 and subpart H preclearance)
• Involvement with other critical operational workstreams may include (but not limited to) print vendor and fulfillment, Veeva CRM platform, budget management and field collaboration
• Support the implementation of existing and new systems, platforms, and processes to support cross‑functional teams while proactively identifying opportunities to drive efficiencies and effectiveness as the business evolves
• Help elevate, oversee, and continuously improve the commercial operations function
• Effectively collaborate to ensure alignment and success with cross‑functional partners including Medical, Regulatory, Legal, Compliance, Marketing, IT, Field Teams, Market Access, Agencies, Vendors, etc.
• Manage multiple vendor and agency partners to drive critical workstreams forward, ensure appropriate resource allocation and timely delivery within financial constraints

Key Job Requirements

• Proactive, self‑starter motivated by challenges and delivering results (business owner mindset)
• High learning agility and problem‑solving skills with ability to multi‑task across several projects
• Strong analytical skills to quickly diagnose problems and develop fit‑for‑purpose solutions
• Ability to work independently while also partnering with cross‑functional teams
• Strong project management skills with proven success in delivering results
• Ability to execute and thrive in fast‑paced environments filled with ambiguity
• Superb communication skills, both verbal and written
• Demonstrated expertise in managing Veeva PromoMats, Smartsheet, SharePoint and Microsoft Office
• Desire to professionally develop and gain more responsibilities resulting in greater impact
• Limited travel – up to 25 % of the time (including weekends as needed)
• Required to be in office 3 days per week (Conshohocken, PA or Waltham, MA)

Education / Experience

• Bachelor’s Degree
• 7+ years of biopharmaceutical marketing and/or operations experience
• Must have direct experience with promotional review committee operations (Veeva Vault/PromoMats)
• 2+ years of experience in project management
• Experience in smaller company (or team) environments is a plus

Total Rewards & Benefits

• Base salary estimate: $150,000 – $184,000 per year (determined by qualifications, skills, education, experience, business needs and market demands)
• Equity participation for all full‑time employees, reinforcing an ownership culture
• Bonus eligibility
• Comprehensive benefits including:
  • Flexible paid time off
  • Medical, dental, vision, and life/disability insurance
  • 401(k) offerings (traditional, Roth, and employer match)
  • Voluntary benefits such as supplemental life insurance and legal services
  • Employee Assistance Program providing mental health support for employees and their families
• Additional benefits provided in accordance with applicable federal, state, and local laws.