Internship

About 4Dcell

Join 4Dcell and become part of a pioneering French biotech on a mission to transform drug discovery and toxicology. We’re engineers and biologists united by a single goal: to replace animal testing with intelligent, in vitro “organ-in-a-well” models that deliver unprecedented predictive power to drive tomorrow’s therapies.

4Dcell has developed two flagship solutions: the SmartHeart™ Platform, which recreates human ventricular tissue in a standard 96-well plate, and the first-in-class SmartSphero™ Technology, enabling the generation of a wide range of organoids.

You’ll collaborate with leading biophysicists, engineers, and biologists to tackle the toughest health challenges, from heart failure and immuno-oncology to pancreas and renal diseases. We combine ambition with a supportive, curiosity-driven culture.

Why intern with us?

• Responsibility to structure and lead your own projects
• Hands-on exposure to game-changing technologies
• Apply marketing skills on a new, growing, exciting and revolutionary market
• A team that values collaboration, growth, and fun
• Membership in a high-energy, fast-growing team developing truly game-changing, high-tech products
• The opportunity to navigate both a commercial start-up environment and an R&D scientific setting
• Close collaboration with experts in technology, marketing, sales, application science and operations
• Step into a role where your work accelerates drug discovery, improves patient outcomes, and builds a more ethical pharmaceutical future.

Context

Within our R&D team, you will work hands-on with experimental protocols to characterize cardiac pathologies and cardiac cell line maturation.

Main Responsibilities

Executing Design of Experiments (DoE)

• Prepare culture media and reagent dilutions
• Seed cells at defined densities according to the DoE matrix
• Record all steps and observations in the lab notebook (LIMS/Excel)

Data Processing & Analysis

• Import raw metrics (viability, marker expression, contractility)
• Create summary tables and plots to compare conditions
• Draft concise experimental summaries with actionable conclusions

3D Cell Culture

• Set up cardiac organoid (SmartHeart)
• Conduct immunofluorescent staining and confocal imaging
• qPCR analysis

Deliverables

• Complete experimental records (DoE details, raw results, observations)
• Analyzed datasets with clear graphical outputs
• Updated operational protocols
• Brief reports for each experimental campaign

Environment & Tools

• Equipment: CO₂ incubators, laminar-flow hoods, confocal microscope
• Software: LIMS/Excel, GraphPad Prism, R or basic Python notebooks
• Techniques: DoE, 2D & 3D cell culture, immunofluorescence

Candidate Profile

• Master’s student in Biology, Biotechnology or Biomedical Engineering
• Hands-on experience with cell culture (2D and/or 3D)
• Comfortable with data entry and analysis
• Experienced in Cellular & Molecular Biology
• Organized, experimentally rigorous and proactive
• Good technical English

It is a plus if the candidate has:

• Background in cardiac biology
• Proficiency in 3D cell models, organoids, or MPS (Microphysiological Systems)
• Knowledge of (cardiac) electrophysiology

Duration & Terms

• 6-month internship, starting September 2026
• Based in Montreuil
• Legal internship stipend + partial transport reimbursement

Rémunération : 650,00€ à 700,00€ par mois

Lieu du poste : En présentiel